Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance.

ABSTRACT: Almost half of individuals diagnosed with schizophrenia also present with a substance use disorder, however, little is known about potential molecular mechanisms underlying this comorbidity. We used genetic analyses to enhance our understanding of the molecular overlap between these conditions. Our analyses revealed a positive genetic correlation between schizophrenia and the following dependence phenotypes: alcohol (r_g = 0.368, SE = 0.076, P = 1.61 × 10^-6), cannabis use disorder (r_g = 0.309, SE = 0.033, P = 1.97 × 10^-20) and nicotine (r_g = 0.117, SE = 0.043, P = 7.0 × 10^-3), as well as drinks per week (r_g = 0.087, SE = 0.021, P = 6.36 × 10^-5), cigarettes per day (r_g = 0.11, SE = 0.024, P = 4

SUBMITTER: Greco LA 

PROVIDER: S-EPMC9508072 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature