Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice.

ABSTRACT: Interleukin-18 (IL18) is an inflammatory cytokine that is related to psychiatric disorders such as depression and cognitive impairment. We previously found that IL18 deficiency may cause hippocampal impairment, resulting in depression-like behavioral changes. However, the potential role of IL18 in stressful conditions remains uncertain. In the present study, we examined the effect of IL18 on neural inflammation and stress tolerance during acute stress. Littermate Il18^+/+ and Il18^-/- mice were exposed to a single restraint stress for 6 h, and all assessments were performed 18 h after the mice were released from the restraint. In Il18^-/- mice exposed to acute stress, the immobility times in both the forced swim test and tail suspension test were decreased, al

SUBMITTER: Yamanishi K 

PROVIDER: S-EPMC9508168 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature