Prognostic value of hepatocyte growth factor for muscle-invasive bladder cancer.

ABSTRACT:

Purpose

The HGF/MET pathway is involved in cell motility, angiogenesis, proliferation, and cancer invasion. We assessed the clinical utility of plasma HGF level as a prognostic biomarker in patients with MIBC.

Methods

We retrospectively analyzed 565 patients with MIBC who underwent radical cystectomy. Logistic regression and Cox regression models were used, and predictive accuracies were estimated using the area under the curve and concordance index. To estimate the clinical utility of HGF, DCA and MCID were applied.

Results

Plasma HGF level was significantly higher in patients with advanced pathologic stage and LN metastasis (p = 0.01 and p < 0.001, respectively). Higher HGF levels were associated with an increased risk of harboring LN metastasis and non-organ-confin

SUBMITTER: Katayama S 

PROVIDER: S-EPMC9508199 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature