Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable.

ABSTRACT: Physiologically-based pharmacokinetic and cellular kinetic models are used extensively to predict concentration profiles of drugs or adoptively transferred cells in patients and laboratory animals. Models are fit to data by the numerical optimisation of appropriate parameter values. When quantities such as the area under the curve are all that is desired, only a close qualitative fit to data is required. When the biological interpretation of the model that produced the fit is important, an assessment of uncertainties is often also warranted. Often, a goal of fitting PBPK models to data is to estimate parameter values, which can then be used to assess characteristics of the fit system or applied to inform new modelling efforts and extrapolation, to inform a prediction under new conditions.

SUBMITTER: Brown LV 

PROVIDER: S-EPMC9508223 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature