Actin cable formation and epidermis-dermis positional relationship during complete skin regeneration.

ABSTRACT: Up to a certain developmental stage, a fetus can completely regenerate wounds in the skin. To clarify the mechanism of fetal skin regeneration, identifying when the skin switches from fetal-type wound regeneration to adult-type wound repair is necessary. We hypothesized that this switch occurs at several time points and that complete skin regeneration requires epidermal-dermal interactions and the formation of actin cables. We compared normal skin and wound morphology at each developmental stage. We examined two parameters: epidermal texture and dermal structure. We found that the three-dimensional structure of the skin was completely regenerated in full-thickness skin incisions made before embryonic day (E) 13. However, the skin texture did not regenerate in wounds made after E14. We also

SUBMITTER: Takaya K 

PROVIDER: S-EPMC9508246 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature