Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway.

ABSTRACT: Early use of florfenicol (FFC) can adversely affect the health of broilers. Our previous studies showed that FFC caused kidney injury in broilers. However, the mechanism by which FFC causes nephrotoxicity remains unclear. In order to further explore the regulatory effect of FFC on specific signal pathway in the injured kidneys and the interaction between genes and proteins in this signal pathway, the transcriptome and proteome sequencing were performed on the chick kidneys in the control group and the FFC treatment group. Then, the sequencing data were analyzed, and the screened genes and proteins were verified by real-time quantitative PCR (qPCR) and parallel reaction monitoring (PRM), respectively. The results of sequencing showed that FFC exposure altered significantly the expression le

SUBMITTER: Wang X 

PROVIDER: S-EPMC9508351 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature