Puerarin improves skeletal muscle strength by regulating gut microbiota in young adult rats.

ABSTRACT:

Background

Sarcopenia is an age-related skeletal muscle dysfunction syndrome that is lacking validated treatments. Maximizing muscle strength in young adulthood may be a promising way to prevent sarcopenia in the elderly. The phytomolecule puerarin has been extensively used in clinical practice and reported to increase energy metabolism in skeletal muscle by directly targeting the skeletal muscle fiber. However, the bioavailability of puerarin is very poor, and almost 93% of puerarin stays in the intestine until excretion. Therefore, we hypothesize that puerarin may regulate gut microbiota to improve skeletal muscle strength and/or mass in adults.

Methods

Twenty three-month old male Sprague Dawley rats were divided into two groups according to average weights, puerarin group

SUBMITTER: Yang W 

PROVIDER: S-EPMC9508383 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature