The dataset for the inflammatory response during experimental infection and treatment of dogs with Babesia rossi.

ABSTRACT: Babesia rossi causes severe morbidity and mortality in dogs in sub-Saharan Africa. This was an experimental study designed to observe systemic changes caused by Babesia rossi infection within a canine disease model as well as investigate the influence of inoculum dose and treatment on the progression of inflammation and clinical disease. Six healthy male beagle dogs formed the study population, one dog was splenectomised and used to raise the infectious inoculum, three were administered a high B. rossi infectious dose and two a low infectious dose. Clinical examination, complete blood count (CBC) and C-reactive protein (CRP) were determined daily. Cytokines were quantified on stored plasma collected during the study, using a canine specific cytokine magnetic bead panel

SUBMITTER: Atkinson BK 

PROVIDER: S-EPMC9508437 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature