Ontology highlight
ABSTRACT:
SUBMITTER: Schulze AS
PROVIDER: S-EPMC9508565 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Schulze Amadeus Samuel AS Kleinau Gunnar G Krakowsky Rosanna R Rochmann David D Das Ranajit R Worth Catherine L CL Krumbholz Petra P Scheerer Patrick P Stäubert Claudia C
iScience 20220906 10
The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened available vertebrate genome data and found that GPR84 is present in vertebrates for more than 500 million years but absent in birds and a pseudogene in bats. Cloning and functional characterization of several mammalian GPR84 orthologs in combination with evolutiona ...[more]