Reduced gut microbiota diversity in patients with congenital generalized lipodystrophy.

ABSTRACT:

Background

Previous studies suggest intestinal dysbiosis is associated with metabolic diseases. However, the causal relationship between them is not fully elucidated. Gut microbiota evaluation of patients with congenital generalized lipodystrophy (CGL), a disease characterized by the absence of subcutaneous adipose tissue, insulin resistance, and diabetes since the first years of life, could provide insights into these relationships.

Methods

A cross-sectional study was conducted with patients with CGL (n = 17) and healthy individuals (n = 17). The gut microbiome study was performed by sequencing the 16S rRNA gene through High-Throughput Sequencing (BiomeHub Biotechnologies, Brazil).

Results

The median age was 20.0 years old, and 64.7% were female. There was no differe

SUBMITTER: Montenegro Junior RM 

PROVIDER: S-EPMC9508722 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature