The Transcriptome Profile of Retinal Pigment Epithelium and Muller Cell Lines Protected by Risuteganib Against Hydrogen Peroxide Stress.

ABSTRACT: Purpose: Oxidative stress contributes to the pathogenesis of vision-impairing diseases. In the retina, retinal pigment epithelium (RPE) and Müller cells support neuronal homeostasis, but also contribute to pathological development under stressed conditions. Recent studies found that the investigational drug risuteganib (RSG) has a good safety profile, provided protection in experimental models, and improved visual acuity in patients. The present in vitro study evaluated the effects of RSG in RPE and Müller cell lines stressed with the oxidant hydrogen peroxide (H₂O₂). Methods: Human RPE (ARPE-19) and Müller (MIO-M1) cell lines were treated with various combinations of RSG and H₂O₂. Trypan blue assay was used to

SUBMITTER: Shao Z 

PROVIDER: S-EPMC9508878 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature