Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer.

ABSTRACT:

Purpose

Altered DNA methylation, genetic alterations, and environmental factors are involved in tumorigenesis. As a tumor suppressor gene, abnormal EPHA5 methylation was found in gastric cancer (GC) tissues and was linked to the initiation, progression and prognosis of GC. In this study, the EPHA5 methylation level in peripheral blood leukocytes (PBLs) was detected to explore its relationship with GC risk and prognosis.

Methods

A total of 366 GC cases and 374 controls were selected as the subjects of this study to collect their environmental factors, and the EPHA5 methylation status was detected through the methylation-sensitive high-resolution melting method. Logistic regression analysis was utilized to evaluate the associations among EPHA5 methy

SUBMITTER: Han X 

PROVIDER: S-EPMC9508887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature