Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the CNS. The etiology of MS is complex, and results from the interaction of multiple environmental and genetic factors. Although human leukocyte antigen-HLA alleles such as HLA-DR2 and -DR3 are considered the strongest genetic factors, the environmental factors responsible for disease predisposition are not well understood. Recently, diet and gut microbiota have emerged as an important environmental factors linked to the increased incidence of MS. Especially, western diets rich in protein and fat have been linked to the increased incidence of obesity. Numerous clinical data indicate a role of obesity and gut microbiota in MS; however, the mechanistic link between gut microbiota and obesity in

SUBMITTER: Shahi SK 

PROVIDER: S-EPMC9509138 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature