Bioinformatics analysis of inflammation and oncology in pulmonary lymphangioleiomyomatosis.

ABSTRACT: This study investigates the molecular markers and biological pathways of pulmonary lymphangioleiomyomatosis. We analyzed 2 gene expression profiles in the gene expression omnibus Gene Expression Omnibus database for normal lung tissue and lymphangioleiomyomatosis and identified differential expressed genes in pulmonary lymphangioleiomyomatosis. Ninety-one differentially expressed genes were identified, including 36 upregulated genes and 55 downregulated genes. Hub genes and pathogenic pathways associated with disease development were subsequently identified by enrichment analysis and protein-protein interaction network. Analysis showed that differential expressed genes are mainly involved in the biological behavior of tumor cell proliferation and invasion as well as the inflammatory respon

SUBMITTER: Su W 

PROVIDER: S-EPMC9509179 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature