KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.

ABSTRACT:

Objectives

To analyze the tissue heterogeneity of hormone-sensitive and drug-resistant nephrotic syndrome genes using a bioinformatics approach and to analyze gene-related functional pathways.

Methods

The limma package of R software was used to screen differential genes from the nephropathy datasets GSE145969 and GSE189734. The differential genes were analyzed for functional and pathway enrichment in terms of biological processes, cellular components, and molecular functions. The Metascape tool was used to construct protein networks for the differential genes, and the results were imported into Cytoscape software for visualization. The genes were identified as key modules and genes using the MCODE plug-in. Gene set enrichment analysis was performed for the HALLMARK analysis

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9509277 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature