CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance.

ABSTRACT: Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players. The CXC motif chemokine subfamily is the second largest family, and it is further subdivided into ELR motif CXC (ELR+) and non-ELR motif (ELR-) CXC chemokines, which are effective chemoattractants for neutrophils and lymphocytes/monocytes, respectively. These chemokines and their receptors are expected to have a significant impact on a wide range of lung diseases, many of which have inflammatory or immunological underpinnings. As a result, manipulations of this subfamily of chemokines and their receptors using small molecular agents and other means have been explored for potential therapeutic benefit in the setting of sev

SUBMITTER: Komolafe K 

PROVIDER: S-EPMC9509283 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature