Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway.

ABSTRACT: Melatonin (MT), a neurohormone with immunomodulatory properties, is one of the metabolites produced in the brain from tryptophan (TRP) that has already strong links with the neuropathogenesis of Multiple sclerosis (MS). However, the exact molecular mechanisms behind that are not fully understood. There is some evidence showing that MS and MT are interconnected via different pathways: Relapses of MS has a direct correlation with a low level of MT secretion and a growing body of evidence suggest that MT be therapeutic in Experimental Autoimmune Encephalomyelitis (EAE, a recognise animal model of MS) severity. Previous studies have demonstrated that the kynurenine pathway (KP), the main pathway of TRP catabolism, plays a key role in the pathogenesis of MS in humans and in EAE. The present stu

SUBMITTER: Jand Y 

PROVIDER: S-EPMC9509376 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature