Association Between Acute Kidney Injury and Dementia in the Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Rationale & objective

Acute kidney injury (AKI) causes biochemical changes in the brain in animal models and is associated with adverse neurological complications in hospitalized patients. This study tested the association between AKI and incident dementia in a community-based cohort.

Study design

Prospective cohort study.

Setting & participants

Adult participants in the Atherosclerosis Risk in Communities (ARIC) study who experienced hospitalized AKI compared with participants hospitalized for other reasons (primary analysis, mean follow-up period 4.3 years) or participants without hospitalized AKI (secondary analysis).

Predictors

Incident AKI, defined by ICD codes from hospital records.

Outcome

Incident dementia, diagnosed based on a combination of neu

SUBMITTER: Tung S 

PROVIDER: S-EPMC9509404 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature