Genetics, epigenetics, and transcriptomics of preterm birth.

ABSTRACT: Preterm birth contributes significantly to neonatal mortality and morbidity. Despite its global significance, there has only been limited progress in preventing preterm birth. Spontaneous preterm birth (sPTB) results from a wide variety of pathological processes. Although many non-genetic risk factors influence the timing of gestation and labor, compelling evidence supports the role of substantial genetic and epigenetic influences and their interactions with the environment contributing to sPTB. To investigate a common and complex disease such as sPTB, various approaches such as genome-wide association studies, whole-exome sequencing, transcriptomics, and integrative approaches combining these with other 'omics studies have been used. However, many of these studies were typically small or

SUBMITTER: Jain VG 

PROVIDER: S-EPMC9509423 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature