Associations between TERT Promoter Mutations and Survival in Superficial Spreading and Nodular Melanomas in a Large Prospective Patient Cohort.

ABSTRACT: Survival outcomes in melanoma and their association with mutations in the telomerase reverse transcriptase gene TERT promoter remain uncertain. In addition, few studies have examined whether these associations are affected by a nearby common germline polymorphism or vary on the basis of melanoma histopathological subtype. We analyzed 408 primary tumors from a prospective melanoma cohort for somatic TERT^-124[C>T] and TERT^-146[C>T] mutations, the germline polymorphism rs2853669, and BRAF^V600 and NRAS^Q61 mutations. We tested the associations between these variants and clinicopathologic factors and survival outcomes. TERT^-124[C>T] was associated with thicker tumors, ulceration, mitoses (>0/mm²), nodular histotype, and CNS involv

SUBMITTER: Chang GA 

PROVIDER: S-EPMC9509439 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature