Reactive Oxygen Species Responsive Cleavable Hierarchical Metallic Supra-Nanostructure.

ABSTRACT: A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported. HMSN structured with thin branches composed of primary gold (Au) nanocrystals and silver (Ag) nano-linkers is synthesized by a one-pot aqueous synthesis with a selected ratio of Au/Ag/cholate. ROS responsive degradability of HMSN is tested in the presence of endogenous and exogeneous ROS. Significant ROS-responsive structural deformation of HMSN is observed in the ROS exposure with hydrogen peroxide (H₂ O₂ ) solution. The ROS responsiveness of HMSN is significantly comparable with negligible structural changes of conventional spherical gold nanoparticles. The demonstrated ROS responsive degradation of HMSN is further confirmed in various in vitro ROS cond

SUBMITTER: Choi H 

PROVIDER: S-EPMC9509447 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature