Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.

ABSTRACT: Several polygenic risk scores (PRSs) have been developed to predict the risk of colorectal cancer (CRC) in European descendants. We used genome-wide association study (GWAS) data from 22 702 cases and 212 486 controls of Asian ancestry to develop PRSs and validated them in two case-control studies (1454 Korean and 1736 Chinese). Eleven PRSs were derived using three approaches: GWAS-identified CRC risk SNPs, CRC risk variants identified through fine-mapping of known risk loci and genome-wide risk prediction algorithms. Logistic regression was used to estimate odds ratios (ORs) and area under the curve (AUC). PRS_115-EAS , a PRS with 115 GWAS-reported risk variants derived from East-Asian data, validated significantly better than PRS_115-EUR derived from European descenda

SUBMITTER: Ping J 

PROVIDER: S-EPMC9509464 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature