Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa.

ABSTRACT:

Background & aims

Dysplasia carries a high risk of cancer development; however, the cellular mechanisms for dysplasia evolution to cancer are obscure. We have previously identified 2 putative dysplastic stem cell (DSC) populations, CD44v6^neg/CD133⁺/CD166⁺ (double positive [DP]) and CD44v6⁺/CD133⁺/CD166⁺ (triple positive [TP]), which may contribute to cellular heterogeneity of gastric dysplasia. Here, we investigated functional roles and cell plasticity of noncancerous Trop2⁺/CD133⁺/CD166⁺ DSCs initially developed in the transition from precancerous metaplasia to dysplasia in the stomach.

Methods

Dysplastic organoids established from active Kras-induced mouse stomachs were used

SUBMITTER: Min J 

PROVIDER: S-EPMC9509466 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature