Early-life factors associated with neurobehavioral outcomes in preterm infants during NICU hospitalization.

ABSTRACT:

Background

The aim of this study was to investigate the influence of early-life pain/stress and medical characteristics on neurobehavioral outcomes in preterm infants.

Methods

A prospective cohort study was conducted with 92 preterm infants (28-32 weeks gestational age [GA]). Early-life pain/stress was measured via the Neonatal Infant Stressor Scale (NISS) during the first 28 days of NICU hospitalization. Neurobehavioral outcomes were evaluated using the NICU Network Neurobehavioral Scale at 36-38 weeks post-menstrual age. Functional regression and machine learning models were performed to investigate the predictors of neurobehavioral outcomes.

Results

Infants experienced daily acute pain/stress (24.99 ± 7.13 frequencies) and chronic events (41.13 ± 17.81 h). Up to 12

SUBMITTER: Zhao T 

PROVIDER: S-EPMC9509490 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature