Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression

ABSTRACT:

Background

Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets. Among them, the expression of some PDZ-containing polarity proteins, as DLG1 and hScrib, is altered during the HPV life cycle and the consequent malignant transformation. Together with the well-established interference of E6 with PDZ proteins, we have recently shown that E7 viral oncoprotein is also responsible for the changes in abundance and localization of DLG1 observed in HPV-associated lesions. Given that the mechanisms involved remained only partially understood, we here thoroughly analyse the contribution of a crucial E7 post-t

SUBMITTER: Dizanzo M 

PROVIDER: S-EPMC9509620 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature