Computer grading of lung disease severity in patients with lymphangioleiomyomatosis referred for transplantation

ABSTRACT:

Objectives

Lymphangioleiomyomatosis (LAM) patients with severe lung disease may be considered for lung transplantation. Clinical, physiologic, and quality of life data are usually employed for referral. The aim of this study was to determine whether computed tomographic measurement of lung volume occupied by cysts (cyst score) complemented clinical and physiologic data in supporting referral for transplantation.

Methods

Forty-one patients were studied. Pre-referral clinical data, pulmonary function tests, exercise testing, and high-resolution computed tomography (HRCT) scans were obtained. From HRCT, a computer-aided diagnostic program was employed to calculate cyst scores. These data were compared to those of 41 age-matched LAM patients not referred for lung transplantat

SUBMITTER: Taveira-DaSilva A 

PROVIDER: S-EPMC9509628 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature