Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish.

ABSTRACT: Melanoma heterogeneity and plasticity underlie therapy resistance. Some tumour cells possess innate resistance, while others reprogramme during drug exposure and survive to form persister cells, a source of potential cancer cells for recurrent disease. Tracing individual melanoma cell populations through tumour regression and into recurrent disease remains largely unexplored, in part, because complex animal models are required for live imaging of cell populations over time. Here, we applied tamoxifen-inducible creERt2/loxP lineage tracing to a zebrafish model of MITF-dependent melanoma regression and recurrence to image and trace cell populations in vivo through disease stages. Using this strategy, we show that melanoma persister cells at the minimal residual disease site originate from th

SUBMITTER: Travnickova J 

PROVIDER: S-EPMC9509888 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature