Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL₃ domain in solution.

ABSTRACT: Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contrast to other signalling mediators, MALT1 is not only activated through the formation of the CBM complex together with the proteins CARMA1 and Bcl10, but also by acting as a protease that cleaves multiple substrates to promote lymphocyte proliferation and survival via the NF-κB signalling pathway. Herein, we present the partial ¹H, ¹³C Ile/Val/Leu-Methyl resonance assignment of

SUBMITTER: Han X 

PROVIDER: S-EPMC9510110 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature