Development and validation of novel sepsis subphenotypes using trajectories of vital signs.

ABSTRACT:

Purpose

Sepsis is a heterogeneous syndrome and identification of sub-phenotypes is essential. This study used trajectories of vital signs to develop and validate sub-phenotypes and investigated the interaction of sub-phenotypes with treatment using randomized controlled trial data.

Methods

All patients with suspected infection admitted to four academic hospitals in Emory Healthcare between 2014-2017 (training cohort) and 2018-2019 (validation cohort) were included. Group-based trajectory modeling was applied to vital signs from the first 8 h of hospitalization to develop and validate vitals trajectory sub-phenotypes. The associations between sub-phenotypes and outcomes were evaluated in patients with sepsis. The interaction between sub-phenotype and treatment with balanced c

SUBMITTER: Bhavani SV 

PROVIDER: S-EPMC9510534 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature