Breast microbiome associations with breast tumor characteristics and neoadjuvant chemotherapy: A case-control study.

ABSTRACT:

Background

Commensal microbiota have been proven to colonize the mammary gland, but whether their composition is altered in patients with breast cancer (BC) remains elusive. This study intends to explore the breast microbiome differences between benign and malignant diseases and to investigate the impact of neoadjuvant chemotherapy (NAC) on the breast microbiota in patients with BC.

Methods

Breast normal adipose tissues (NATs) were collected from 79 patients with BC and 15 controls between July 2019 and November 2021. The BC group consisted of 29 patients who had received NAC and 50 who were non-NAC patients. Participants diagnosed with benign breast disease were recruited as controls. 16S rRNA gene sequencing was used to analyze the bacterial diversity of NATs.

Results</

SUBMITTER: Li X 

PROVIDER: S-EPMC9510588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature