The regulatory network of potential transcription factors and MiRNAs of mitochondria-related genes for sarcopenia.

ABSTRACT: Background: Mitochondrial dysfunction is a significant contributor to sarcopenia, but the mechanism remains unclear. Methods: In the present study, we downloaded GSE117525 and GSE8479 datasets from Gene Expression Omnibus (GEO), then the weighted correlation network analysis (WGCNA) was used to construct scale-free co-expression networks respectively. The key genes of aging muscle were obtained by overlapping key modules of two networks. Receiver operating characteristic (ROC) curve was drawn to explore the diagnostic efficacy of key genes. Finally, a transcription factor-key gene network was constructed based on ChEA3 platform and hTFtarget database, and a miRNA-key gene network was constructed using starBase and the multimiR R package. Results: The most positively or

SUBMITTER: Fu W 

PROVIDER: S-EPMC9510666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature