Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer.

ABSTRACT:

Background

Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined.

Methods

By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues.

Results

The expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. Th

SUBMITTER: Gao L 

PROVIDER: S-EPMC9510761 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature