Role of ground-glass opacity in pure invasive and lepidic component in pure solid lung adenocarcinoma for predicting aggressiveness

ABSTRACT:

Objective

Lung adenocarcinoma often includes noninvasive components with postoperative lepidic morphology on pathologic specimens that appear on preoperative high-resolution computed tomography (HRCT) images as ground-glass opacity (GGO). We aimed to disclose the role of GGO on the aggressiveness of pathologically confirmed pure invasive tumors in patients with early-stage lung adenocarcinoma.

Methods

The prognosis of 932 patients with clinical stage 0-IA and pathologic node-negative lung adenocarcinoma who underwent lobectomy at 3 institutions between 2010 and 2016 was investigated according to the status of GGO and lepidic components.

Results

The recurrence-free survival (RFS) of patients with pathologically confirmed pure invasive tumors was worse without (n =

SUBMITTER: Mimae T 

PROVIDER: S-EPMC9510793 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature