Association of low-grade inflammation caused by gut microbiota disturbances with osteoarthritis: A systematic review.

ABSTRACT:

Background

Currently, many studies have been published on the relationship between the gut microbiome and knee osteoarthritis. However, the evidence for the association of gut microbiota with knee osteoarthritis has not been comprehensively evaluated.

Objective

This review aimed to assess existing results and provide scientific evidence for the association of low-grade inflammation caused by gut microbiota disturbances with knee osteoarthritis.

Methods

This study conducted an extensive review of the current literature using four databases, PubMed, EMBASE, Cochrane Library and Web of Science before 31 December 2021. Risk of bias was determined using ROBINS and SYRCLE, and quality of evidence was assessed using GRADE and CAMADARES criteria. Twelve articles were included

SUBMITTER: Xiang W 

PROVIDER: S-EPMC9510893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature