Mathematical characterization of population dynamics in breast cancer cells treated with doxorubicin.

ABSTRACT: The development of chemoresistance remains a significant cause of treatment failure in breast cancer. We posit that a mathematical understanding of chemoresistance could assist in developing successful treatment strategies. Towards that end, we have developed a model that describes the cytotoxic effects of the standard chemotherapeutic drug doxorubicin on the MCF-7 breast cancer cell line. We assume that treatment with doxorubicin induces a compartmentalization of the breast cancer cell population into surviving cells, which continue proliferating after treatment, and irreversibly damaged cells, which gradually transition from proliferating to treatment-induced death. The model is fit to experimental data including variations in drug concentration, inter-treatment interval, and number of d

SUBMITTER: Yang EY 

PROVIDER: S-EPMC9510895 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature