Immunophenotypes of anti-SARS-CoV-2 responses associated with fatal COVID-19.

ABSTRACT:

Background

The relationship between anti-SARS-CoV-2 humoral immune response, pathogenic inflammation, lymphocytes and fatal COVID-19 is poorly understood.

Methods

A longitudinal prospective cohort of hospitalised patients with COVID-19 (n=254) was followed up to 35 days after admission (median, 8 days). We measured early anti-SARS-CoV-2 S1 antibody IgG levels and dynamic (698 samples) of quantitative circulating T-, B- and natural killer lymphocyte subsets and serum interleukin-6 (IL-6) response. We used machine learning to identify patterns of the immune response and related these patterns to the primary outcome of 28-day mortality in analyses adjusted for clinical severity factors.

Results

Overall, 45 (18%) patients died within 28 days after hospitalisation. We iden

SUBMITTER: Selb J 

PROVIDER: S-EPMC9510901 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature