Prognostic value of glycolysis markers in pancreatic cancer: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Previous studies have investigated the prognostic significance of glycolysis markers in pancreatic cancer; however, conclusions from these studies are still controversial.

Methods

PubMed, Embase, and Web of Science were systematically searched to investigate the prognostic role of glycolysis markers in pancreatic cancer up to May 2022. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) related to overall survival (OS), disease free survival (DFS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS) were calculated using the STATA 12.0 software.

Results

A total of 28 studies comprising 2010 patients were included in this meta-analysis. High expression of the five glycolysis markers was correlated with a poorer OS (HR = 1

SUBMITTER: Wang C 

PROVIDER: S-EPMC9510923 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature