Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.

ABSTRACT:

Background

Cognitive impairment and cerebral microbleeds (CMBs) are long-term side-effects of cranial radiation therapy (RT). Previously we showed that memory function is disrupted in young patients and that the rate of cognitive decline correlates with CMB development. However, vascular injury alone cannot explain RT-induced cognitive decline. Here we use resting-state functional MRI (rsfMRI) to further investigate the complex mechanisms underlying memory impairment after RT.

Methods

Nineteen young patients previously treated with or without focal or whole-brain RT for a brain tumor underwent cognitive testing followed by 7T rsfMRI and susceptibility-weighted imaging for CMB detection. Global brain modularity and efficiency, and rsfMRI signal variability within the dorsal a

SUBMITTER: Morrison MA 

PROVIDER: S-EPMC9511024 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature