The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs.

ABSTRACT:

Background

Urethral sphincter mechanism incompetence (USMI) is a common problem in female dogs, but some dogs fail to achieve continence with standard treatment. Urethral submucosal injection of autologous skeletal muscle progenitor cells (skMPCs) previously has been shown to restore urethral function in a canine model of USMI.

Hypothesis/objective

To determine if urethral submucosal injection of skMPC alters continence in dogs with USMI that had previously failed standard medical management. We hypothesized that the injections would lead to improved continence.

Animals

Fifteen client-owned dogs with USMI that had failed standard medical management.

Methods

Dogs were prospectively enrolled into a single-armed clinical trial. Once enrolled, a triceps muscle of e

SUBMITTER: Vaden SL 

PROVIDER: S-EPMC9511066 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature