Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study.

ABSTRACT:

Background

Nausea and emesis can be, among other signs, common manifestations of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as maropitant and metoclopramide, are used commonly, but do not appear to control nausea. A non-placebo-controlled preliminary study suggested good efficacy of 5-HT3-receptor antagonists, such as ondansetron, against nausea in dogs with vestibular syndrome.

Objectives

To assess and confirm the effect of ondansetron on behavior suggestive of nausea in dogs with vestibular syndrome.

Animals

Fourteen dogs with vestibular syndrome and clinical signs of nausea presented to a neurology service.

Methods

Placebo-controlled, double-blinded, crossover study. Behavioral assessment was performed hourly for 4 hours u

SUBMITTER: Henze L 

PROVIDER: S-EPMC9511069 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature