Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats.

ABSTRACT:

Background

In people and dogs, torasemide has higher bioavailability, longer half-life, and longer duration of action than equivalent doses of furosemide but data regarding pharmacological properties of torasemide in cats are limited.

Objective

To assess pharmacokinetic and pharmacodynamic parameters of torasemide in healthy cats, and to investigate the effects of a single administration of torasemide on indicators of diuresis, plasma creatinine concentration, blood pressure, electrolyte concentrations and markers of the renin-angiotensin-aldosterone system (RAAS).

Animals

Six clinically healthy adult European shorthair cats.

Methods

Randomized 4-period crossover design with 3 groups and 4 treatments. Pharmacokinetic parameters were obtained using a noncompartm

SUBMITTER: Roche-Catholy M 

PROVIDER: S-EPMC9511087 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature