Airway pathogens detected in stable and exacerbated COPD in patients in Asia-Pacific.

ABSTRACT:

Background

The burden of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region is projected to increase. Data from other regions show bacterial and viral infections can trigger acute exacerbations of COPD (AECOPD).

Methods

This 1-year prospective epidemiological study (ClinicalTrials.gov identifier: NCT03151395) of patients with moderate to very severe COPD in Hong Kong, the Philippines, South Korea and Taiwan assessed the prevalence in sputum samples (by culture and PCR) of bacterial and viral pathogens during stable COPD and AECOPD. The odds of experiencing an exacerbation was evaluated for pathogen presence, acquisition and apparition. Health-related quality of life (HRQOL) was assessed.

Results

197 patients provided 983 sputum samples, with 226 p

SUBMITTER: Taddei L 

PROVIDER: S-EPMC9511156 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature