Screening of plasma exosomal lncRNAs to identify potential biomarkers for obstructive sleep apnea.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is highly prevalent, but frequently undiagnosed. The existing biomarkers of OSA are relatively insensitive and inaccurate. Long non-coding RNAs (lncRNAs) have no protein-coding ability but have a role in regulating gene expression. They are stably expressed in exosomes, easily and rapidly measurable. Changes in expression of exosomal lncRNAs can be useful for disease diagnoses. However, there are few reports on the association of exosomal lncRNAs with OSA. We aimed to investigate the exosomal lncRNA profiles to establish the differences between non-OSA, OSA with or without hypertension (HTN) and serve as a potential diagnostic biomarker.

Methods

This diagnostic test included 63 participants: [normal control (NC) =25], (OSA =23), and (

SUBMITTER: Chen X 

PROVIDER: S-EPMC9511177 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature