Lung cancer with brain metastases remaining in continuous complete remission due to pembrolizumab and temozolomide: a case report

ABSTRACT:

Background

Immunotherapy has been shown to improve the overall survival (OS) in patients with advanced or metastatic non-small cell lung cancer (NSCLC) without driver gene mutations. However, monotherapy with immunotherapy alone or combined with chemotherapy in NSCLC patients with untreated brain metastases (BM) is still under debate. Data regarding treatment of BM with immunotherapy and temozolomide (TMZ) in patients with NSCLC is rare.

Case Presentation

A 60-year-old male due to cough and expectoration presented in our hospital. Chest computed tomography (CT), brain magnetic resonance imaging (MRI) and immunohistochemistry of a mediastinal lymph node biopsy were administered, he was diagnosed with stage IIIB lung adenocarcinoma. Without driver gene mutations, he was tre

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9511178 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature