Mechanisms of immune-related differentially expressed genes in thyroid-associated ophthalmopathy based on the GEO database.

ABSTRACT:

Background

We performed a differential analysis, enrichment analysis, and immune-infiltration analysis of the thyroid-associated ophthalmopathy (TAO) gene using data from the Gene Expression Omnibus (GEO) database to provide a theoretical basis for understanding the immune-related mechanisms of TAO.

Methods

We searched the GEO database for "Graves disease" and selected the genes expressed in the lacrimal gland of thyroid-related eye disease patients as the test group and the genes expressed in the lacrimal gland of normal subjects as the control group. Immune-related differentially expressed genes (irDEGs), gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein-protein interaction, gene-gene interaction (GGI) network, pivotal gene identification,

SUBMITTER: Gao Y 

PROVIDER: S-EPMC9511181 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature