Modification of m6A mediates tissue immune microenvironment in calcific aortic valve disease.

ABSTRACT:

Background

Several human diseases are associated with aberrant expression of regulators involved in N6-methyladenosine (m6A) RNA modification. However, their role in aortic valve calcification (AVC) is largely unknown. The aim of this study was to determine the general expression pattern and potential function of m6A regulators in AVC by bioinformatics methods.

Methods

We obtained AVC datasets from the Gene Expression Omnibus (GEO). The identification of m6A-related differentially expressed genes (DEGs) and the Consensus Clustering method was performed to type AVC individuals based DEGs. Then, we quantified the effect of typing by principal component analysis (PCA). Next, we performed the weighted gene co-expression network analysis (WGCNA) and identified the main modules as

SUBMITTER: Chen JY 

PROVIDER: S-EPMC9511183 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature