Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population.

ABSTRACT:

Objective

To evaluate the relationship between alanine transaminase (ALT) level and biphasic insulin secretion (BPIS) in healthy elderly Han Chinese individuals.

Methods

This cross-sectional study enrolled healthy elderly participants aged ≥60 years that were part of a health examination programme. In order to explore the correlation and severity of the clinical condition, those with any possible confounding factors known to affect insulin secretion or liver function were excluded from the study. BPIS was calculated using an equation developed previously by this research team.

Results

This study enrolled 39 845 healthy elderly individuals (19 058 males and 20 787 females). Participants were stratified into four quartile groups according to their ALT level. In both mal

SUBMITTER: Wu TY 

PROVIDER: S-EPMC9511325 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature