Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.

ABSTRACT:

Background and objective

The reduction of forced expiratory volume in 1 s (FEV₁ ) in response to methacholine challenge in asthma may reflect two components: airway narrowing, assessed by the change in FEV₁ /forced vital capacity (FVC), and airway closure, assessed by the change in FVC. The purpose of this study was to determine the degree and determinants of airway closure in response to methacholine in a large group of asthmatic patients participating in studies conducted by the American Lung Association-Airways Clinical Research Centers (ALA-ACRC).

Methods

We used the methacholine challenge data from participants in five studies of the ALA-ACRC to determine the closing index, defined as the contribution of airway closure to the decrease in FEV_1<

SUBMITTER: Kaminsky DA 

PROVIDER: S-EPMC9511501 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature