Melatonin for the prevention of postoperative delirium in older adults: a protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Postoperative delirium (POD) is a major cause of morbidity, particularly in elderly patients. Melatonin has been suggested as a low-risk pharmacological intervention to help prevent POD. A previous systematic review found limited high-quality evidence to support the use of melatonin in the prevention of POD. Several further randomised studies have since been published. This systematic review aims to synthesise the evidence from randomised controlled trials (RCTs) examining the effect of melatonin on the prevention of POD in older adults.

Methods and analysis

A systematic search of RCTs of melatonin (any dose and formulation) in POD will be run across Embase, Medline, CINAHL and PsychInfo. RCTs published from January 1990 until the end of February 2022 and report

SUBMITTER: Sewart E 

PROVIDER: S-EPMC9511532 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature