Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method.

ABSTRACT:

Objectives

Cardiovascular disease is increasing in many low and middle-income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations.

Design

A cross-sectional study conducted in a longitudinal family cohort.

Setting

Research unit within a tertiary hospital in a historically disadvantaged, large urban township of South Africa.

Participants

195 individuals from 65 biological families with all three generations including third-generation children aged 4-10 years were recruited from the longest running intergenerational cohort study in Africa, the Birth to Twenty Plus cohort. All adults

SUBMITTER: Ware LJ 

PROVIDER: S-EPMC9511591 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature